Mycotoxin Binder Research

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Mycotoxin binder research that does not fall under a category with an article devoted to it, ends up on this page.  This page is being set up currently. There are specific articles on binders that can be found at:

Binders - What Are They

Types of Binders

Using Binders To Remove Mycotoxins


Evaluation of the ability of Saccharomyces cerevisiae and mannan oliosaccharides to ameliorate the adverse effects of aflatoxin B1 in broiler chickens

Published on:2/28/2019
Author/s : Rashant A. Khatke, Ram Singh*, A.B. Mandal And Praveen K. Tyagi. / Mycotoxin Laboratory, Avian Nutrition and Feed Technology Division, Central Avian Research Institute, Izatnagar - 243 122 (U.P.).
The efficacy of Saccharomyces cerevisiae (SC) and mannan oligosaccharides (MOS) alone or in combinations as aflatoxin binders in the diets of broiler chickens containing 300 ppb aflatoxin B1 was investigated. A total of 320 day-old broiler chicks were divided into 10 treatment groups (T1 - control; T2 - T1 + 300 ppb AFB1 ; T3 - T2 + 0.05% MOS; T4 - T2 + 0.1% MOS; T5 - T2 + 0.2% MOS; T6 - T2 + 0.05% SC; T7 - T2 + 0.1% SC; T8 - T2 + 0.2% SC; T9 - T2 + 0.05% MOS+ 0.05% SC; T10 - T2 + 0.1% MOS + 0.1% SC). Each diet was offered from day-old to 42 days of age to four replicated groups of 8 birds each. During overall growth period (0-6 weeks), the body weight gain (BWG) of broiler in control group (T1 ) was 1450.0 g which significantly (P<0.05) reduced to 1131.0 g in aflatoxin alone fed group (T2 ). The BWG in other treatments (T3 -T10) varied from 1268.4g in T6 to 1432.1 g in T8 and the values recorded were comparable to that of control group. Inclusion of binders in aflatoxin contaminated diet, alone or in combinations, improved (P<0.05) the BWG during 0-6 weeks growth period. The overall feed consumption in all the treatment groups was statistically similar to that of control group, however, the FI in groups T8 and T9 was statistically higher than that of aflatoxin alone fed group (T2 ). During overall growth period, the FCR in control group was 1.932 which significantly (P<0.05) increased to 2.22 due to administration of aflatoxin. The overall FCR in groups T3 , T6 and T7 was statistically higher than that of control group. This indicated that supplementation of MOS at 0.05% and SC at 0.05 and 0.1% level to the aflatoxin contaminated diet may not be sufficient to curb the harmful effect of aflatoxicosis in broiler diet. Addition of MOS and SC (alone or in combination) improved the livability percentage in broiler chickens. MOS at 0.1 and 0.2% level of inclusion was more effective than their SC counterpart in improving the livability percentage in broiler chickens. It is concluded that aflatoxin in feed at 300 ppb level impaired the performance in the terms of body weight gain, feed intake, feed efficiency and livability in broiler chickens during period of 0- 6 weeks. Use of binders MOS and SC (at the rate 0.05%, 0.1%, 0.2%) and their combination ameliorated the effect of aflatoxin partially or completely in dose-dependent manner. The 0.2% level of MOS and SC is more effective than 0.05% and 0.1% level in counteracting the 300 ppb of aflatoxin in the feed.
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