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Tannins As Toxin Binder

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Tannins As A Mycotoxin Binder Research

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Phytother Res. 2011 Apr;25(4):624-8. doi: 10.1002/ptr.3306. Epub 2010 Oct 5.
Bile acid-binding ability of kaki-tannin from young fruits of persimmon (Diospyros kaki) in vitro and in vivo.
Matsumoto K1, Kadowaki A, Ozaki N, Takenaka M, Ono H, Yokoyama S, Gato N.

Abstract
The bile acid-binding ability of a highly polymerized tannin (kaki-tannin) extracted from dried-young fruits of persimmon (Diospyros kaki) was examined. The kaki-tannin was composed mainly of epicatechin, epigallocatechin, epicatechin-3-O-gallate and epigallocatechin-3-O-gallate. Bile acid-binding ability of kaki-tannin was examined against cholic acid, glycocholic acid, taurocholic acid and deoxycholic acid in vitro, and its effect on fecal bile acid excretion in mice was also examined. Although the bile acid-binding ability of kaki-tannin was weaker than that of cholestyramine, kaki-tannin adsorbed all the bile acids tested and significantly promoted fecal bile acid excretion in mice when supplied at 1% (w/w) in the diet.
Copyright © 2010 John Wiley & Sons, Ltd.
PMID: 20922818 [PubMed - indexed for MEDLINE]

 

Ann Nutr Metab. 2013;62(1):1-6. doi: 10.1159/000343787. Epub 2012 Nov 17.
Persimmon fruit tannin-rich fiber reduces cholesterol levels in humans.
Gato N1, Kadowaki A, Hashimoto N, Yokoyama S, Matsumoto K.

Abstract
Bile acid-binding agents are known to lower blood cholesterol levels and have been clinically used for the treatment of hypercholesterolemia. We previously showed that tannin-rich fiber from young persimmon (Diospyros kaki) fruits had bile acid-binding properties. In this study, we performed a randomized, double-blind, placebo-controlled trial to investigate the hypocholesterolemic effects of tannin-rich fiber in humans. The subjects (n = 40, plasma total cholesterol levels 180-259 mg/dl) were divided into 3 groups and ingested cookie bars containing 0 g (placebo group, n = 14), 3 g (low-dose group, n = 13), or 5 g (high-dose group, n = 13) of tannin-rich fiber 3 times daily before meals for 12 weeks. Plasma total cholesterol levels decreased significantly in the low-dose (12 weeks, p < 0.005) and high-dose (6 weeks, p < 0.05; 12 weeks, p < 0.001) groups. In addition, plasma low-density lipoprotein cholesterol levels decreased significantly in the high-dose group (6 weeks, p < 0.05; 12 weeks, p < 0.001). These improvements were not accompanied by changes in plasma high-density lipoprotein cholesterol or plasma triglyceride levels. Our findings indicate that tannin-rich fiber from young persimmon fruits is a useful food material for treating hypercholesterolemia.
Copyright © 2012 S. Karger AG, Basel.
PMID: 23171573 [PubMed - indexed for MEDLINE]

 

Nat Prod Res. 2012;26(23):2255-8. doi: 10.1080/14786419.2011.650640. Epub 2012 Jan 18.
Water-insoluble condensed tannins content of young persimmon fruits-derived crude fibre relates to its bile acid-binding ability.
Takekawa K1, Matsumoto K.

Abstract
In this study, we prepared crude fibre samples from young fruits of 10 persimmon (Diospyros kaki) cultivars and from young fruits of Japanese pear (Pyrus pyrifolia var. culta) and peach (Prunus persica) and compared their bile acid-binding abilities in vitro. All crude fibre samples from young fruits of persimmon were able to bind to cholic acid in a 4 mM cholic acid solution, but crude fibre samples from young fruits of Japanese pear and peach did not show bile acid-binding ability. The bile acid-binding ability was strongly correlated with the water-insoluble condensed tannins content in crude fibre samples (r = 0.909, p < 0.001). These results indicate that the water-insoluble condensed tannins content in young fruits of persimmon is related to its bile acid-binding ability.
PMID: 22250751 [PubMed - indexed for MEDLINE]

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