Urine Tests For Mycotoxins
Testing urine for mycotoxins can be helpful if you want to see if your patient has a specific mycotoxin load or to follow how severe that load is.
If the person is unable to transform/detoxify the mycotoxins, they will not show up in the urine. So, a negative result could be that the person has no mycotoxins or it could be that the person has tons of mycotoxins in their tissue and is not able to detoxify them adequately and remove them in the urine. To help them move the mycotoxins out prior to urine collection for the test, they can use near infrared saunas or other methods of sweating such as a hot tub or regular sauna for ten-30 minutes before urine collection. (Not tolerated by everyone and not to be used with a patient with POTS or adrenal insufficiency.) As an alternative they can also use liposomal glutathione or acetyl glutathione 500 mg two times per day for a week prior to the urine collection to mobilize the mycotoxins so they will show up in the urine. Either of these methods will mobilize toxins and it may make the person feel worse. If the person feels worse, this means they are mobilizing mycotoxins and they don't need to wait for a week on the glutathione, they can take the urine test immediately.
There are additional lab tests that can help to identify biotoxin illness such as CIRS-due to water-damaged buildings (mold illness).
Real Time Laboratories
Real Time Laboratories (RTL) offers testing for three types of mycotoxins in the urine using ELISA technology that relies on antibodies.
They are Tricothecenes, Aflatoxins and Ochratoxin .
Tricothecenes are evaluated by using Enzyme-Linked ImmunoSorbant Assay (ELISA). The test at RTL has been validated as a qualitative test. Thus, RTL reports whether tricothecenes are PRESENT or NOT PRESENT.
Aflatoxins are evaluated using ImmunoSorbant Columns containing antibodies to the group of aflatoxins (B1, B2, G1, and G2). Results are reported as PRESENT or NOT PRESENT.
Ochratoxin A is evaluated using immunoSorbant Columns containing antibodies to the Ochratoxin A. Results are reported as PRESENT or NOT PRESENT.
Specimens that have been validated are urine, sputum, nasal washes, tissues. To discuss cost of these tests, please call the laboratory. You don't usually find mycotoxins in the blood as macrophages pick them up and remove them by storing in tissue.
Great Plains Laboratory
Great Plains Laboratory has a test called GPL-MycoTOX Profile that uses liquid chromatography mass spectrometry (LC-MS/MS) technology. They claim to be able to detect amounts in the parts per trillion for many of the mycotoxins they test. They test 8 mycotoxins that are commonly made by the molds Aspergillus, Penicillium, Stachybotrys, and Fusarium. Some of these mycotoxins may be made by other molds also, but are most commonly associated wtih these molds.
Aspergpillus: aflatoxin, ochratoxin, patulin and fumigillin - includes aflatoxin M1 which is the main metabolite of aflatoxin B1.
Stachybotrys: roridin E and verrucarin
Fusarium: zearalenone and fumonisin
has a mycotoxin test called GPL-MycoTOX Profile that includes aflatoxin M1 which is the main metabolite of aflatoxin B1.
You might be confused when you see their chart. There is a results column which is obvious. Next you will see a "Common Range of Positive Results" They list a range of numbers there. The number on the left is the number they consider the maximum safe amount of mycotoxins before symptoms will appear. The number on the right is the number that 75% of the patients who have sent in samples have. Anything above this is considered extremely elevated.
As of 2018 they are able to detect over 40 different strains of disease-causing mold. Here is a table that illustrates all of the different mold species that they can now detect:
Vibrant Wellness offers a urine-based assay for 31 of the most common mycotoxins produced by molds to which humans are exposed. This test is measured on their proprietary microarray platform, to produce the most accurate and clinically relevant assessment of difficult-to-detect toxins that can cause serious disease in humans. The mycotoxins they test for are listed below.
- Aflatoxin M1
- Ochratoxin A
- Roridin E(Trichothecenes)
- Verrucarin A (Trichothecenes)
- Enniatin B1
- Fumonisins B1
- Fumonisins B2
- Fumonisins B3
- Aflatoxin B1
- Aflatoxin B2
- Aflatoxin G1
- Aflatoxin G2
- Mycophenolic Acid
- Chaetoglobosin A
- Nivalenol (NIV)
- Diacetoxyscirpenol (DAS)
- T-2 toxin (rare)
- Satratoxin G (Trichothecenes)
- Satratoxin H (Trichothecenes)
- Isosatratoxin F (Trichothecenes)
- Roridin A (Trichothecenes)
- Roridin H (Trichothecenes)
- Roridin L-2 (Trichothecenes)
- Verrucarin J (Trichothecenes)
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